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KMID : 0644320000060010047
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Journal of Korean Oriental Oncology
2000 Volume.6 No. 1 p.47 ~ p.65
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Antitumor and Immunomodulator Effects of Hyangsapyungwisan in ICR-mice
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하지용/Ha, Jee-Yong
조영호/이지숙/Jo, Young-Ho/Lee, Jee-Suk
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Abstract
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In order to investigate annumor and immune response effect by Hyangsapyungwisan after Sarcoma-
180 cells and methotrexate were treared each other. the extract of Hyangsapyungwisan was orally
administered to ICR mice for 14 days.
To evaluate the effects of the Hyangsapyungwisan, 50% inhibition concentration(IC_50), mean survival days, tumor weight for antitumor effects, hemagglutinin titer, hemolysin titer, rosette forming cells,
natural killer cell and productivity of interleukin-2 for immune responses measured in ICR mice.
The results were summarized as follows:
1. Mean survival time in Hyangsapyungwisan-treated group was slightly prolonged, as compared with control group(13.46%).
2. On the MTT assay, cell viability was significantly inhibited by 5ug/well, 2.5ug/well, l.25ug/well.
and 0.625ug/well of Hyangsapyung-wism concentration inhibited cell viability significantly. IC_5o for cell viability was 11.59ug/well.
3. Tumor weight in Hyangsapyungwisan treated group was depressed, as compared with the control group(P<0.05).
4. Hemagglutinin titer in Hyangsapyungwisan-treated group was slightly increased with no
significance, as compared with the control group.
5. Hemolysin titer in Hyangsapyungwisan-treated group was silightly increased, as compared with the control group(P<0.05).
6. Rosette forming cells in Hyangsapyungwisan-treated group was silightly increased, as compared with the control group(P<0.05).
7. Naural killer cell activity in Hyangsapyungwisan-treated group was significantly increased(P<0.05).
8. Production of interleukin-2 was significantly increased(P<0.05).
According to the above results, Hyangsapygwisan had prominent antitumor, and enhance both cellular and humoral immunity in mice.
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